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Use of cow urine for treatment of ascites, heart failure, renal failure and vitiligo has been elaborately described in Sushruta Samhita, suggesting that ancient Indians had some understanding of steroidal properties of cow urine around 6th century BCE. DHT, via its metabolite 3α-androstanediol (produced by 3α-hydroxysteroid dehydrogenase (3α-HSD)), is a neurosteroid that acts via positive allosteric modulation of the GABAA receptor. AAS that have a high potential for aromatization like testosterone and particularly methyltestosterone show a high risk of gynecomastia at sufficiently high dosages, while AAS that have a reduced potential for aromatization like nandrolone show a much lower risk (though still potentially significant at high dosages). AAS that are 17α-alkylated (and not also 4,5α-reduced or 19-demethylated) are also aromatized but [where to buy anabolic steroids](https://www.freakscene.net/smf/index.php?topic=2343.0) a lesser extent than is testosterone. 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In horses, for example, anabolic steroids can cause liver damage and weakening of the tendons and can result in decreased testis size and sperm production in stallions and altered reproductive cycling in mares. The use of anabolic steroids is either forbidden or closely controlled in most human and some equine sports. Anabolic steroids are commonly abused by human athletes to build muscle and improve strength.